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Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis
Circulation Research, 06/22/09

Hooper AT et al. – Results show that the vascular-specific marker angiomodulin (AGM) modulates vascular remodeling in part by temporizing the proangiogenic effects of vascular endothelial growth factor (VEGF)-A.

• Study of whether AGM modulates VEGF-A–dependent vascular patterning
• Creation of an AGM knock-in reporter mouse; use of a zebrafish model

• AGM predominantly expressed in vasculature of developing embryos and adult organs
• During physiological and pathological angiogenesis, AGM upregulated in angiogenic vasculature
• In zebrafish model, AGM restricted to developing vasculature by 17 to 22 hs postfertilization
• Blockade of AGM activity with morpholino oligomers results in prominent angiogenesis defects in vascular sprouting and remodeling
• Concurrent knockdown of both AGM and VEGF-A results in synergistic angiogenesis defects
• With overexpressed VEGF-A, simultaneous injection of AGM morpholino oligomers blocks VEGFR-2/flk-1 (VEGF-A receptor compensatory induction)

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