Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Pre-participation screening of young competitive athletes for prevention of sudden cardiac death 3. The Job Market for 2008-2009: Compensation 4. Renal Artery Stenosis 5. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease
Your Article Summary
See Latest ArticlesImpact of androgen deprivation therapy on cardiovascular disease and diabetes
Journal of Clinical Oncology, 06/12/09
Alibhai SMH et al. - In a study to clarify whether androgen deprivation therapy (ADT) is associated with an increased risk of both acute myocardial infarction (AMI) and cardiovascular mortality, it was shown that continuous ADT use for at least 6 mos in older men is associated with increased risk of diabetes and fragility fracture but not AMI or sudden cardiac death.
Methods- Using linked administrative databases, men age 66 yrs or older with prostate cancer (PC) given continuous ADT for at least 6 mos or who underwent bilateral orchiectomy (n = 19,079) were matched with men with PC who had never received ADT.
- Treated and untreated groups were matched 1:1 (ie, hard-matched) on age, prior cancer treatment, and yr of diagnosis and propensity-matched on comorbidities, medications, cardiovascular risk factors, prior fractures, and socioeconomic variables.
- Primary outcomes were development of AMI, sudden cardiac death, and diabetes; fragility fracture was also examined.
- The cohort was observed for a mean of 6.47 yrs.
- In time-to-event analyses, ADT use was associated with an increased risk of diabetes and fragility fracture but not with AMI or sudden cardiac death.
- Increasing duration of ADT was associated with excess risk of fragility fractures and diabetes but not cardiac outcomes.
Related Articles
Increased incidence of cardiovascular events in patients with antineutrophil cytoplasmic antibody-associated vasculitides: A matched-pair cohort study
Arthritis & Rheumatism, 11/05/09
Relevance Score: 71%
Chronic renal insufficiency, cardiovascular disease and mortality in women: a causal relationship or coincidence?
Women's Health, 11/02/09
Relevance Score: 70%
Cardiovascular morbidity and mortality remain similar in two cohorts of patients with long-standing rheumatoid arthritis seen in 1978 and 1995 in Malmö, Sweden
Rheumatology, 10/30/09
Relevance Score: 70%
Frequency of migraine and the risk of cardiovascular disease for women: limited evidence of an association
Women's Health, 10/30/09
Relevance Score: 69%
Systemic lupus erythematosus and the risk of cardiovascular disease: Results from the Nurses Health Study
Arthritis Care and Research, 10/01/09
Relevance Score: 69%
Today in Coronary Artery Disease...keeping you current
Receive free subspecialty "5-minute updates" via email
Altered composition of triglyceride-rich lipoproteins and coronary artery disease in a large case–control study
Atherosclerosis, 12/04/09
CYP4A11 polymorphism correlates with coronary endothelial dysfunction in patients with coronary artery disease—The ENCORE Trials
Atherosclerosis, 12/04/09
Serum amyloid A induction of cytokines in monocytes/macrophages and lymphocytes
Atherosclerosis, 12/04/09
Sponsor
Article Search
Sponsor
Sponsor