Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Pre-participation screening of young competitive athletes for prevention of sudden cardiac death 3. The Job Market for 2008-2009: Compensation 4. Renal Artery Stenosis 5. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease
Your Article Summary
See Latest ArticlesHNF1A gene variants and cardiovascular risk factors in individuals with late-onset autosomal dominant diabetes: A cross-sectional study
Cardiovascular Diabetology, 06/05/09
Giuffrida FMA et al. – Late onset autosomal dominant diabetes mellitus (LOADDM) is clinically indistinguishable from classic type 2 diabetes mellitus ((CT2DM). However, LOADDM group is enriched for common HNF1A polymorphisms A98V and S487N. I27L showed "protective effect" on hypertriglyceridemia, suggesting a role for HNF1A on the diabetic pt lipid profile. These data contribute to the understanding of the complex interactions between genes, hyperglycemia and cardiovascular risk factors development in T2DM.
Methods- Study of the relationship of HNF1A SNPs with cardiovascular risk factors in LOADDM and characterization in contrast to CT2DM
- Assessment of 18 LOADDM pts (age at onset > 40 yrs; diabetes in 3 contiguous generations, uniparental lineage) with 48 CT2DM pts and 42 normoglycemic controls (N group)
- LOADDM showed significantly higher frequencies of SNPs A98V and S487N of HNF1A vs CT2DM
- I27L did not show significant difference but associated with lower risk of hypertriglyceridemia
- Protective effect" independent from other well-known predictive risk factors for hypertriglyceridemia, such as waist circumference and HDL on logistic regression
Related Articles
Emerging Risk Factors for Coronary Heart Disease: A Summary of Systematic Reviews Conducted for the U.S. Preventive Services Task Force
Annals of Internal Medicine, 10/07/09
Relevance Score: 84%
Increased incidence of cardiovascular events in patients with antineutrophil cytoplasmic antibody-associated vasculitides: A matched-pair cohort study
Arthritis & Rheumatism, 11/05/09
Relevance Score: 83%
Cardiovascular risk factors and collateral artery formation
European Journal of Clinical Investigation, 10/26/09
Relevance Score: 83%
25-hydroxyvitamin D and cardiovascular risk factors in women with systemic lupus erythematosus
Arthritis Care and Research, 10/01/09
Relevance Score: 83%
Inequalities in cardiovascular disease mortality: The role of behavioural, physiological and social risk factors
Journal of Epidemiology and Community Health, 10/29/09
Relevance Score: 82%
Today in Basic Science/Genetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Insights into the Pathogenesis and Genetic Background of Patency of the Ductus Arteriosus
Neonatology, 12/08/09
Lack of association between alpha-adducin G460W polymorphism and hypertension: evidence from a case–control study and a meta-analysis
Journal of Human Hypertension, 12/08/09
Context Dependent Associations between Variation in Risk of Ischemic Heart Disease and Variation in the 5' Promoter Region of the Apolipoprotein E Gene in Danish Females
Circulation: Cardiovascular Genetics, 12/08/09
Today in Coronary Artery Disease...keeping you current
Receive free subspecialty "5-minute updates" via email
Upregulation of PTEN by CKD712, a synthetic tetrahydroisoquinoline alkaloid, selectively inhibits lipopolysaccharide-induced VCAM-1 but not ICAM-1 expression in human endothelial cells
Atherosclerosis, 12/08/09
Effect of Intensive Statin Therapy on Clinical Outcomes Among Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome
JACC - Journal of the American College of Cardiology, 12/08/09
Influence of body mass index on extent of coronary atherosclerosis and cardiac events in a cohort of patients at risk of coronary artery disease
Nutrition, Metabolism & Cardiovascular Diseases, 12/08/09
Sponsor
Article Search
Sponsor
Sponsor