Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Pre-participation screening of young competitive athletes for prevention of sudden cardiac death 3. The Job Market for 2008-2009: Compensation 4. Renal Artery Stenosis 5. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease
Your Article Summary
Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: Results From the MIRACL (Myocardial Ischemia Reduction With Aggressive Cholesterol Lowering) trial
JACC - Journal of the American College of Cardiology, 06/08/09
Fraley AE et al. – In pts with acute coronary syndromes (ACS), baseline levels of oxidative biomarkers varied by specific cardiovascular disease (CVD) risk factors and were largely independent of inflammatory biomarkers. Atorvastatin uniformly increased oxidized phospholipids (OxPL)/apolipoprotein B particles (apoB) levels in all subgroups. Future studies must assess whether the increase in OxPL/apoB levels reflects the benefit of effective therapeutic interventions and prediction of new CVD events.
Methods- Study of relationship between oxidative biomarkers, CVD risk factors, and inflammatory and thrombosis biomarkers
- Measurement of OxPL/apoB, lipoprotein (a) [Lp(a)], and oxidized low-density lipoprotein (OxLDL) biomarkers
- OxLDL biomarkers: immunoglobulin (Ig)G and IgM autoantibodies to malondialdehyde (MDA)-low-density lipoprotein (LDL) and IgG and IgM apoB-100 immune complexes (IC/apoB)
- Assessment at baseline and after 16 wks of treatment with atorvastatin 80 mg/day or placebo
- Subjects: 2,342 ACS pts enrolled in MIRACL
- At baseline, potentially atheroprotective IgM autoantibodies and IgM IC/apoB lower in male pts, diabetic pts, and pts age >65 yrs
- Higher levels of OxPL/apoB, Lp(a), and OxLDL biomarkers for pts with LDL levels greater vs less than the median (122 mg/dL)
- Atorvastatin resulted in significantly larger changes in all biomarkers in female pts, pts age <65 yrs, pts with LDL cholesterol <122 mg/dl, nonsmokers, and nondiabetic pts
- A significant increase in OxPL/apoB in response to atorvastatin in all 20 subgroups
- Weak or no significant correlations between all OxLDL biomarkers and C-reactive protein, serum amyloid A, tissue plasminogen activator, interleukin-6, intercellular adhesion molecule, vascular cell adhesion molecule, P-selectin, and E-selectin at randomization and 16 wks
Related Articles
Statin-independent prognosis of patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP therapy
Annals of Oncology, 11/06/09
Relevance Score: 68%
Systematic Review: Comparative Effectiveness and Harms of Combination Therapy and Monotherapy for Dyslipidemia
Annals of Internal Medicine, 11/03/09
Relevance Score: 68%
Statin prophylaxis and inflammatory mediators following cardiopulmonary bypass: a systematic review
Critical Care, 10/27/09
Relevance Score: 68%
Are High-Risk Hypertensive Patients being Prescribed Concomitant Statin Therapy?: A Retrospective Cohort Study
American Journal of Cardiovascular Drugs, 10/07/09
Relevance Score: 68%
Statin therapy initiated in a man with hepatitis C and elevated cholesterol
The Clinical Advisor, 10/07/09
Relevance Score: 67%
Today in Atherosclerosis/Lipids...keeping you current
Receive free subspecialty "5-minute updates" via email
Atorvastatin Inhibits gp91phox Circulating Levels in Patients With Hypercholesterolemia
Arteriosclerosis, Thrombosis, and Vascular Biology, 12/17/09
Peroxisome Proliferator-Activated Receptor-gamma Coactivator 1-alpha Overexpression Prevents Endothelial Apoptosis by Increasing ATP/ADP Translocase Activity
Arteriosclerosis, Thrombosis, and Vascular Biology, 12/16/09
Identification of Two Common Variants Contributing to Serum Apolipoprotein B Levels in Mexicans
Arteriosclerosis, Thrombosis, and Vascular Biology, 12/16/09
Today in Basic Science/Genetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Pleiotropy of C-Reactive Protein Gene Polymorphisms With C-Reactive Protein Levels and Heart Rate Variability in Healthy Male Twins
The American Journal of Cardiology, 12/17/09
GNB3 C825T Polymorphism and Elevated Blood Pressure
International Journal of Sports Medicine, 12/17/09
Peroxisome Proliferator-Activated Receptor-gamma Coactivator 1-alpha Overexpression Prevents Endothelial Apoptosis by Increasing ATP/ADP Translocase Activity
Arteriosclerosis, Thrombosis, and Vascular Biology, 12/16/09
Today in Clinical Pharmacology...keeping you current
Receive free subspecialty "5-minute updates" via email
A randomized, double-blind, four-arm parallel-group study of the efficacy and safety of azelnidipine and olmesartan medoxomil combination therapy compared with each monotherapy in Japanese patients with essential hypertension: the REZALT study
Hypertension Research, 12/17/09
Evaluation of arterial stiffness in morning hypertension under high-dose valsartan compared to valsartan plus low-dose diuretic
Hypertension Research, 12/17/09
Atorvastatin Inhibits gp91phox Circulating Levels in Patients With Hypercholesterolemia
Arteriosclerosis, Thrombosis, and Vascular Biology, 12/17/09
Today in Inflammation...keeping you current
Receive free subspecialty "5-minute updates" via email
Toll-Like Receptor-2 Mediates Inflammation and Matrix Degradation in Human Atherosclerosis
Circulation, 12/16/09
Promotion of direct angiogenesis in vitro and in vivo by Puerariae flos extract via activation of MEK/ERK-, PI3K/Akt/eNOS-, and Src/FAK-dependent pathways
Phytotherapy Research, 12/16/09
Comparison of the long-term prognostic value of Cystatin C to other indicators of renal function, markers of inflammation and systolic dysfunction among patients with acute coronary syndrome
Atherosclerosis, 12/11/09
Sponsor
Article Search
Sponsor
Sponsor


See Latest Articles


