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See Latest ArticlesBeta-blockade with nebivolol in elderly heart failure patients with impaired and preserved left ventricular ejection fraction: Data from SENIORS (Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors With Heart Failure)
JACC - Journal of the American College of Cardiology, 06/08/09
van Veldhuisen DJ et al. – Findings show the effect of beta-blockade with nebivolol in elderly heart failure (HF) pts was similar in pts with preserved and impaired ejection fraction (EF).
Methods- Pre-specified subanalysis of the SENIORS trial
- SENIORS: study of effects of nebivolol in elderly HF pts
- Study of effects of left ventricular ejection fraction (EF) on outcomes, including subgroups of impaired EF (≤35%) and preserved EF (>35%)
- Subjects: 2,111 pts; 1,359 (64%) had impaired (≤35%) EF (mean 28.7%) and 752 (36%) had preserved (>35%) EF (mean 49.2%)
- Comparison of effects of nebivolol for interaction of EF with outcome
- Follow-up: 21 mo
- Primary endpoint: all-cause mortality or cardiovascular hospitalizations
- Preserved EF pts: more often women (49.9% vs 29.8%); less advanced HF, more hypertension, and fewer prior myocardial infarctions
- During follow-up, primary endpoint in 465 pts (34.2%) with impaired EF and in 235 (31.2%) with preserved EF
- Effect of nebivolol on primary end point was 0.86 in pts with impaired EF and 0.81 in preserved EF
- Effects on all secondary endpoints similar between groups
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