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See Latest ArticlesA randomized placebo-controlled study on the effect of nifedipine on coronary endothelial function and plaque formation in patients with coronary artery disease: The ENCORE II study
European Heart Journal, 06/04/09
Felix T et al. – The ENCORE II trial shows that calcium channel blockade with nifedipine for up to 2 yrs improves coronary endothelial function added to statin treatment; results did not show an effect of nifedipine on plaque volume.
Methods- Study of effects of a calcium antagonist on coronary endothelial function and plaque size in stable coronary artery disease (CAD)
- In 454 PCI pts, acetylcholine (10–6 to 10–4 M) infused in a coronary segment without significant CAD
- Measurement of changes in coronary diameter
- Intravascular ultrasound examination (IVUS)
- In addition to statin therapy, pts randomized in a double-blind fashion to placebo or nifedipine GITS 30–60 mg/day and followed for 18–24 mo
- Blood pressure lower with nifedipine vs placebo by 5.8/2.1 mmHg
- Total and LDL cholesterol lower with nifedipine vs placebo
- HDL higher cholesterol with nifedipine vs placebo
- In the most constricting segment, nifedipine reduced vasoconstriction to acetylcholine (14.0% vs placebo 7.7%)
- Percentage change in plaque volume: 1.0% nifedipine vs 1.9% placebo
Today in Basic Science/Genetics...keeping you current
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A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: a randomised, double-blind, placebo-controlled trial
The Lancet, 10/27/09
Obesity-Related Cardiorenal Syndrome
The Journal of Clinical Hypertension, 10/20/09
Inflammatory mediators and premature coronary atherosclerosis in rheumatoid arthritis
Arthritis Care and Research , 11/03/09
Today in Clinical Pharmacology...keeping you current
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New Anticoagulants in Atrial Fibrillation
Seminars in Thrombosis and Hemostasis, 10/02/09
New Anticoagulants for Atrial Fibrillation
Seminars in Thrombosis and Hemostasis, 09/15/09
Effectiveness of Two-Year Clopidogrel + Aspirin in Abolishing the Risk of Very Late Thrombosis After Drug-Eluting Stent Implantation (from the TYCOON [Two-Year ClOpidOgrel Need] Study)
The American Journal of Cardiology, 11/05/09
Today in Coronary Artery Disease...keeping you current
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Acute Coronary Syndromes: Diagnosis and Management, Part I
Mayo Clinic Proceedings, 10/05/09
Acute medical management of the non-ST-segment elevation acute coronary syndromes (NSTE-ACS) in older patients
Archives of Gerontology and Geriatrics, 10/14/09
Prognostic value of peak and post-exercise treadmill exercise echocardiography in patients with known or suspected coronary artery disease
European Heart Journal, 10/16/09
Today in Physiology...keeping you current
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Obesity-Related Cardiorenal Syndrome
The Journal of Clinical Hypertension, 10/20/09
Usefulness of Various Plasma Biomarkers for Diagnosis of Heart Failure in Children With Single Ventricle Physiology
The American Journal of Cardiology, 10/27/09
The Effects of Resistance Training on Metabolic Health With Weight Regain
The Journal of Clinical Hypertension, 11/04/09
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