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See Latest ArticlesModalities and future prospects of gene therapy in heart transplantation
European Journal of Cardio-Thoracic Surgery, 05/27/09
Vassalli G et al. - Clinical gene therapy trials in heart transplantation have not yet been started. The best vector and gene to be delivered remain to be identified. Pre-clinical studies in non-human primates are needed. Nonetheless, the potential of gene therapy as an adjunct therapy in transplantation is essentially intact.
Giuseppe Vassalli, 05/28/09
| The rationale for this approach involves production of immunomodulatory, anti-inflammatory and pro-survival factors by the graft tissue itself, thus maximizing local graft protection while minimising general immunosuppression and other systemic side effects. |
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