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Mediterranean diet and incidence of and mortality from coronary heart disease and stroke in women
Circulation, 02/25/09

Fung TT et al. – A greater adherence to the Mediterranean diet, as reflected by a higher Alternate Mediterranean Diet Score, was associated with a lower risk of incident coronary heart disease (CHD) and stroke in women.

Methods

Review of 74,886 women age 38-63 yrs in Nurses' Health Study (cohort study of female nurses) without a history of cardiovascular disease and diabetes
Pts followed from 1984-2004
Calculation of Alternate Mediterranean Diet Score from self-reported dietary data collected through validated food frequency questionnaires administered 6 times between 1984-2002
Cox proportional-hazards models, adjusted for cardiovascular risk factors, to estimate relative risks for incident CHD, stroke, and combined fatal cardiovascular disease

Results

During 20 years of follow-up, 2391 incident cases of CHD, 1763 incident cases of stroke, and 1077 cardiovascular disease deaths (fatal CHD and strokes combined)
Women in top Alternate Mediterranean Diet Score quintile at lower risk for both CHD and stroke vs pts in bottom quintile
Cardiovascular disease mortality significantly lower among women in top quintile of Alternate Mediterranean Diet Score

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