Cardiology Medical News about genes regulating lipid metabolism;antidiabetic drugs

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The effect of antidiabetic drugs on genes regulating lipid metabolism
Current Opinion in Lipidology, 01/09/09

Tomkin GH et al. – Although antidiabetic drugs affect lipid metabolism, little evidence suggests that these drugs can prevent atherosclerosis in diabetes; however, some antidiabetic drugs may promote atherosclerosis through an adverse effect on lipoproteins.

Methods

Literature review for pathways linking abnormalities in fatty acid metabolism, insulin resistance, and diabetes with cholesterol metabolism abnormalities in context of the effect of antidiabetic drugs on lipoprotein metabolism

Results

Postprandial lipoproteins are an established risk factor
Both insulin resistance and diabetes are associated with abnormalities in chylomicron production, with identified clearance and regulatory genes
Metformin has multiple actions affecting numerous genes
Peroxisome proliferator-activated receptor-gamma regulation of insulin sensitivity and important effects on lipoproteins are reported
The entero-insulin axis and glucagon-like peptide-1 agonists, with inhibitors of dipeptidyl peptidase 4 may have lipoprotein implications

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