Cardiology

Your Article Summary

See Latest Articles

Evolution and outcome of diastolic dysfunction
Heart, 12/24/08

Achong N et al. – Diastolic dysfunction (DD) is associated with all-cause mortality, independent of presence of a major co-morbidity; degree of DD remains stable in ~50% of pts, with more favorable outcome for pts whose diastolic function improves over time.

• Cohort study to characterize influence of clinical features, medical therapy, and echocardiographic parameters on DD progression
• Review of 926 consecutive pts (62±14 yrs, 221 women) with DD and preserved systolic function
• Repeat echocardiography in 199 pts >1 yr after baseline study (average 3.6±1.4 yrs)
• Follow-up for 4.8±2.5 years: 97% complete for major endpoint of all-cause mortality

• At follow-up, 142 pts died and 22 admitted with heart failure
• Independent predictors of death: age, hyperlipidemia, co-morbid disease, restrictive filling
• DD degree stable in 52%, deteriorated in 27% and improved in 21%
• More use of medical therapy in pts with stable or worsening diastolic function
• On multivariate analysis considering medical therapy use, improved DD associated with survival benefit

Today in Physiology...keeping you current

Receive free subspecialty "5-minute updates" via email

The Effects of Resistance Training on Metabolic Health With Weight Regain
The Journal of Clinical Hypertension, 11/04/09

Obesity-Related Cardiorenal Syndrome
The Journal of Clinical Hypertension, 10/20/09

Usefulness of Various Plasma Biomarkers for Diagnosis of Heart Failure in Children With Single Ventricle Physiology
The American Journal of Cardiology, 10/27/09

See All of Physiology