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See Latest ArticlesHigh-dose adenosine overcomes the attenuation of myocardial perfusion reserve caused by caffeine
JACC - Journal of the American College of Cardiology, 12/04/08
Reyes E et al. – Caffeine in coffee attenuates adenosine-induced coronary hyperemia and thus detection of perfusion abnormality by adenosine myocardial perfusion scintigraphy (MPS). Increasing the adenosine dose can overcome yhis effect without compromising test tolerability.
Methods- Study of whether an increase in adenosine dose overcomes caffeine antagonism on adenosine-mediated coronary vasodilation
- MPS to assess adenosine-induced hyperemia in 30 pts before (baseline) and after coffee ingestion (caffeine)
- Baseline administration of 140 µg/kg/min of adenosine combined with low-level exercise
- For caffeine study, 12 pts received 140 µg/kg/min of adenosine (standard); 18 pts received 210 µg/kg/min (high dose) after caffeine intake (200 mg)
- Semiquantitative and quantitative assessment of myocardial perfusion
- Perfusion defect characterized by presence of reversibility
- Caffeine reduced magnitude of perfusion abnormality induced by standard adenosine as measured by summed difference score (SDS) as well as defect size
- Caffeine had no effect on abnormalities caused by high-dose adenosine
- Good agreement between baseline and caffeine studies for segmental defect category in the high-dose group
- An increase in adenosine after caffeine intake was well tolerated
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