Cardiology Medical News about Alpha-Lipoic acid;different formulations

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Pharmacokinetics of different formulations of tioctic (alpha-lipoic) acid in healthy volunteers
Clinical and Experimental Hypertension, 11/21/08

Amenta F et al. – Alpha-lipoic acid (ALA) concentrations accumulated in erytrocytes after administration of different formulations are directly proportional the plasma levels of each formulation.

Methods

Study of 3 ALA formulations with different claimed absorption rates: 2 high absorption (Byodinoral 600 QR, Tiocronal 600 HR); 1 prolonged absorption rate (Tiobec 600 retard)
Comparison of these 3 formulations with German registered formulation (Thioctacid 600 mg HR)
Analysis of plasma and cellular (in erythrocytes) ALA in healthy volunteers/li>
Measured plasma kinetic parameters: area under curve from time 0 to last measured time (AUCt), ALA peak plasma concentration (Cmax), and time (Tmax ) at which Cmax was observed
ALA concentration at different sampling times: only parameter assessed for erythrocytes

Results

AUCt values similar for 4 formulations
Cmax significantly higher for Byodinoral 600 QR and Tiocronal 600 HR vs Thioctacid 600 mg HR or Tiobec 600 retard
Tmax value significantly shorter for Byodinoral 600 QR vs Tiocronal 600 HR, and then Thioctacid 600 mg HR and Tiobec 600 retard

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