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See Latest ArticlesArterial stiffness in insulin resistance: The role of nitric oxide and angiotensin II receptors
Vascular Health and Risk Management, 11/14/08
Brillante DG et al. - Increased AT1R mediated activity in the vasculature is central to the development of increased arterial stiffness and is enhanced in INSR states. AT2R activity is increased in early in INSR and may contribute to the apparent increase in basal NO activity. AT1R blockade may therefore be valuable treatment for early INSR as antagonism of AT1 receptors would allow angiotensin II to act unopposed at AT2 receptors.
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