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See Latest ArticlesEffects of carnitine supplementation on flow-mediated dilation and vascular inflammatory responses to a high-fat meal in healthy young adults
The American Journal of Cardiology, 11/14/08
Volek JS et al. – Findings indicate that carnitine supplementation in healthy pts improves postprandial flow-mediated dilation (FMD) after a high-fat meal.
Methods- Study of the effects of carnitine supplementation on postprandial FMD and circulating biomarkers of inflammation and oxidative stress after a high-fat meal
- Randomized, double-blind, placebo-controlled, crossover study design
- Pts: 30 men and women; age 30 +/- 8 yr, body mass 72.9 +/- 17.1 kg, body fat 13.0 +/- 6.4%
- Two vascular testing days, each preceded by 3 wks of supplementation with either 2 g/day of l-carnitine (l-carnitine l-tartrate) or placebo with a 3- to 5-wk washout period between trials
- Brachial artery FMD in response to 5 min of upper arm occlusion and circulating markers of oxidative stress and inflammation measured in fasting state and afte standard high-fat meal
- After 3 wks of supplementation, peak FMD in fasting state was similar between carnitine and placebo trials, averaging 6.6%
- Peak FMD during postprandial period decreased to 5.8% at 1.5 hrs during placebo and increased to 7.7% during carnitine trial
- Improvement in postprandial vascular function most dramatic in pts (15) who had a decrease in peak FMD in response to the meal
- Significant increase in postprandial lipemia and plasma interleukin-6 but no effect of supplementation
- No significant postprandial changes or supplement effects for plasma tumor necrosis factor-alpha and malondialdehyde
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