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C-reactive protein genotypes associated with circulating C-reactive protein but not with angiographic coronary artery disease: The LURIC study
European Heart Journal, 10/30/08

Grammer TB et al. – No association was found between coronary artery disease (CAD) and genetic polymorphisms (PMs) causing long-term modulation of C-reactive protein concentration, possibly due to either a very small genetic effect size or confounding and reverse causation of a relationship between C-reactive protein and cardiovascular events

Methods

Study of the association between 3 genetic PMs (–717C>T, rs2794521; +1059G>C, rs1800947; +1444C>T, rs1130864) at the C-reactive protein locus and related haplotypes with both circulating C-reactive protein and angiographic CAD

Results

C-reactive protein concentration: similar in stable CAD pts and in controls; increased in pts with acute coronary syndromes
After adjustment for main confounding variables, minor alleles of +1059G>C (rs1800947) and +1444C>T PM (rs1130864) associated with decreased and increased concentrations of C-reactive protein, respectively
Haplotypes 1 and 4 decreased, and haplotype 2 increased C-reactive protein; haplotype 3 had no appreciable effect
None of the genetic variants affecting circulating C-reactive protein consistently associated with prevalence of angiographic CAD

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