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Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction
European Heart Journal, 10/30/08

Huikuri HV et al. – Intracoronary bone marrow cell (BMC) therapy is associated with improvement of global left ventricular ejection fraction (LVEF), neutral effects on arrhythmia risk profile, and re-stenosis of the stented coronary lesions in pts after thrombolytic therapy of ST-elevation myocardial infarction (STEMI)

• Study of the efficacy and safety of BMC therapy in pts treated with thrombolysis and then percutaneous coronary intervention (PCI) 2–6 days after STEMI
• Randomization to intracoronary BMCs (40 pts) or placebo (40)
• Collection and preparation 3–6 hr prior PCI; injection into infarct artery immediately after stenting
• Efficacy assessment: left ventricular angiography and 2-D echocardiography for global LVEF
• Safety assessment: intravascular ultrasound for arrhythmia risk variables and restenosis of stented vessel

• Greater absolute increase of global LVEF at 6 mo for BMC vs placebo group by either angiography or 2-D echocardiography
• No differences between groups in adverse clinical events, arrhythmia risk variables, or minimal lumen diameter of stented coronary lesion

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