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Article Summary

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15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration
Atherosclerosis, 06/26/08

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Danielsson KN et al. - In macrophages, overexpression of 15-LOX-2 results in increased secretion of CXCL10 and CCL2. Products released in response to increased 15-LOX-2 activation lead to increased expression of CD69, the T cell activation marker as well as increased T cell migration. Therefore, increased expression of 15-LOX-2 induced by hypoxia may participate in T cell recruitment in diseases such as atherosclerosis.

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