Eastwood J-A et al. - Compared with patients with low baseline uncertainty, patients with high baseline uncertainty had higher levels of anxiety and depression and lower levels of perceived control and health-related quality of life 1 year after angiography. Baseline health-related quality of life, uncertainty, and life stress accounted for 54% of the variance in health-related quality of life, even when angiographic outcome was controlled for. Baseline uncertainty was independently associated with health-related quality of life. At initial angiography, high levels of uncertainty about illness portend negative health-related quality of life outcomes up to 1 year later.