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Emilio Ortega, et al. – Factors that influence energy metabolism and substrate oxidation, such as thyroid hormones (THs), may be important regulators of body weight...Conclusion: In euthyroid Pima Indians, lower free T3 but not free T4 concentrations were an independent predictor of SMR and lipid oxidation and a predictor of weight gain. This finding indicates that control of T4-to-T3 conversion may play a role in body weight regulation

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