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Article Summary

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Dilated Cardiomyopathy Resulting From High-Level Myocardial Expression of Cre-Recombinase
Journal of Cardiac Failure, 06/08/06

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Conclusion: Cre-recombinase when expressed at high levels may cause organ dysfunction, which could be mistaken for an effect of conditional gene inactivation. In addition, the stereotypic cardiomyopathy and disease progression in the characterized, high-expressing transgenic strain suggests its utility as a model to study the effects of pharmacologic or genetic manipulations in heart failure

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