Dietary carbohydrate modification alters serum metabolic profiles in individuals with the metabolic syndrome
Lankinen M et al. – Results suggest that dietary carbohydrate modification alters the serum metabolic profile, especially in lysoPC species, and thus may contribute to proinflammatory processes that promote adverse changes in insulin and glucose metabolism. Methods- Study of the effect of carbohydrate modification on serum metabolic profiles, including lipids and branched chain amino acids, and dependencies between these and specific gene expression pathways in adipose tissue
- Subjects (20) with metabolic syndrome from larger FUNGENUT study population
- Randomization to either diet high in oat and wheat bread and potato (OWP) or rye bread and pasta (RP)
- Serum metabolomics analyses by ultra-performance liquid chromatography coupled to electrospray ionization mass spectrometry (UPLC/MS), gas chromatography (GC) and UPLC
Results- OWP group: multiple proinflammatory lysophosphatidylcholines increased
- RP group: docosahexaenoic acid (DHA 22:6n-3) increased and isoleucine decreased
- OWP group: mRNA expression of stress reactions- and adipose tissue differentiation-related genes upregulated in adipose tissue
- RP group: downregulated pathways related to stress reactions and insulin signaling and energy metabolism
- Lipid profiles had strongest association with changes in adipose tissue differentiation pathway by elastic net regression model of lipidomic profiles on selected pathways
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