Statins and prevention of atrial fibrillation in patients with heart failure
Liu T et al. – A review of statins and prevention of atrial fibrillation (AF) in heart failure (HF) pts summarizes recent efficacy and outcome data as well as the anti-arrhythmic mechanisms of statin in this setting. Methods- Review of statins and prevention of AF in HF
Results- Statins are highly effective and widely used lipid-lowering agents in clinical practice with pleiotropic properties beyond cholesterol lowering
- Trials show reduced cardiovascular morbidity and mortality in both primary and secondary prevention with statins
- Statins may have beneficial effects on cardiovascular outcomes in HF, specifically in prevention of AF
- Anti-arrhythmic mechanisms of statins regarding AF prevention in HF patients are not fully understood
- Mechanisms may be related to pleiotropic effects: anti-inflammatory, antioxidant, atrial remodeling attenuation, ion channel stabilization, and autonomic nervous system regulation
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