The vascular risk associations with migraine: Relation to migraine susceptibility and progression
Hamed SA et al. – A review of the vascular risk associations with migraine summarizes the relationship to migraine susceptibility and progression. Understanding of migraine as a risk for vascular diseases raises important clinical implications, recommendations, and future perspectives in migraine treatment and prevention. Methods- Review of vascular risk associations with migraine
Results- Changes in cortical excitability, neuroinflammation and dysfunction of the vascular wall contribute to migraine pathophysiology
- Prolonged repeat migraine result in inflammatory arteriopathy of cranial vessels
- Migraine may be associated with special pattern of inflammatory markers and some adverse vascular risk factors
- Risk factors: increased levels of CRP, ILs, TNF-alpha and adhesion molecules
- Factors serve as markers of systemic inflammation, oxidative stress and thrombosis, increased body weight, high blood pressure, hypercholesterolemia, impaired insulin sensitivity, high homocysteine levels, stroke, and coronary heart disease
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