Ventricular reverse remodeling early after mitral valve repair for severe chronic mitral regurgitation with atrial fibrillation
Song BG et al. – Preoperative lower N-terminal B-type natriuretic peptide (NT-proBNP) levels and younger age may predict by left ventricular reverse remodeling (LVRR) early after surgical correction of chronic mitral regurgitation (MR) with atrial fibrillation (AF). Methods- Study of the relation of clinical, echocardiographic findings and NT-proBNP to LVRR early after valve repair for severe chronic MR concomitant with modified maze procedure for AF
- Retrospective evaluation of 60 pts surgically treated for severe chronic MR and AF
- Plasma NT-proBNP and echocardiographic measurements before surgery, before discharge and 12 mo after surgery
- Echocardiogram additionally performed at 6 mo
- LVRR assessed by regression of LV mass index (LVMI) using echocardiography
Results- LVRR group: 52 pts (87%), defined as a postoperative reduction in LVMI
- Remaining pts classified in non-LVRR group
- Non-LVRR group older, had significantly higher ratio of hypertensive pts, higher NT-proBNP levels, and lower ejection fraction vs LVRR group
- In multivariate analysis, age and NT-proBNP levels were independent predictors of LVRR
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