Preservation of Intracellular Renin Expression Is Insufficient to Compensate for Genetic Loss of Secreted Renin
Hypertension, 10/14/2009
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Xu D et al. – The results suggest that preservation of intracellular renin expression in the brain is not sufficient to compensate for a loss of sRen, and sRen plays a pivotal role ... function, survival, and the regulation of arterial pressure.
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Inhibition of calcineurin phosphatase promotes exocytosis of renin from juxtaglomerular cells
Kidney International, 11/16/2009
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Madsen K et al. – The authors aim is to examine the role of the calcium/calmodulin–dependent phosphatase calcineurin in regulation of renin release, they assayed exocytosis using whole–cell patch ... Calcineurin and calcium/calmodulin suppress exocytosis of renin from juxtaglomerular cells independent of PKA.
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Clinical effects of eplerenone, a selective aldosterone blocker, in Japanese patients with essential hypertension
Journal of Human Hypertension, 11/04/2009
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correlations between plasma renin activity or plasma aldosterone concentration (PAC) before eplerenone treatment and blood pressure after eplerenone treatment, showing that the antihypertensive effect of eplerenone is not affected by the patient's renin profile or pretreatment PAC values. Eplerenone
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Familial and Phenotypic Associations of the Aldosterone Renin Ratio
Journal of Clinical Endocrinology and Metabolism, 10/15/2009
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Alvarez–Madrazo S et al. – The ARR is continuously distributed, is influenced by genetic and environmental factors, and is not a marker of a distinct pathological abnormality but possibly reflects the long–term ... endocrinology
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Time-Dependent Effects of Low-Dose Aspirin on Plasma Renin Activity, Aldosterone, Cortisol, and Catecholamines
Hypertension, 10/12/2009
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Snoep JD et al. – Aspirin taken at bedtime compared with on awakening significantly diminished 24–hour plasma renin activity and excretion of cortisol, dopamine, and
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The Biology of the (Pro)Renin Receptor
Journal of the American Society of Nephrology, 11/18/2009
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Nguyen G et al. – The characteristics explain the interest in the potential role of PRR in organ damage in diseases associated with activation of the renin–angiotensin system (RAS), in particular hypertension and diabetes.
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Renal and cardio-protective effects of direct renin inhibition: a systematic literature review
Journal of Hypertension, 11/20/2009
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Lambers Heerspink HJ et al. – Evidence from preclinical and clinical studies suggests that DRIs may have renal and cardiovascular effects beyond their ability to lower blood pressure. Results of ... definitively assess the renal and cardio–protective effects of these agents.
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Natural History of Markers of Collagen Turnover in Patients With Early Diastolic Dysfunction and Impact of Eplerenone
JACC - Journal of the American College of Cardiology, 10/23/2009
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progressive increases in markers of collagen turnover and inflammation in HFPSF with diastolic dysfunction. Despite high background utilization of renin–angiotensin–aldosterone modulators, eplerenone therapy prevents a progressive increase in pro–collagen type–III
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Brain renin-angiotensin system in cognitive function: pre-clinical findings and implications for prevention and treatment of dementia
Acta Neurologica Belgica, 10/20/2009
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Ciobica A et al. – It is believed that central actions of angiotensins are not exclusively associated with their traditional roles, many studies showing that
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The impact of stopping inhibitors of the renin–angiotensin system in patients with advanced chronic kidney disease
Nephrology Dialysis Transplantation, 10/13/2009
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Ahmed AK et al. – Discontinuation of ACEi/ARB has undoubtedly delayed the onset of RRT in the majority of those studied. This observation may justify a rethink of the approach
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