Heat-shock protein 90: A novel autoantigen in human carotid atherosclerosis
Atherosclerosis, 11/12/2009
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Businaro R et al. – The new findings, showing that HSP90 is overexpressed in plaque and serum from patients with atherosclerosis and induces an immune response in these patients, implicate HSP90 as a possible target autoantigen in the pathogenesis of carotid atherosclerosis ... atherosclerosis/lipids
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Prevention of atherosclerosis with low-density lipoprotein cholesterol lowering—lipoprotein changes and interactions: the SANDS study
Journal of Clinical Lipidology, 10/14/2009
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Howard WJ et al. – In diabetic adults with no previous cardiovascular events, treatment to current targets for lipids and systolic blood pressure reduces atherosclerosis ... targets are met, atherosclerosis regresses. The aggressive targets for LDL–C and non–HDL–C appeared to be the main determinants of CIMT regression and were more predictive of this outcome than changes in LDL–P or apoB.
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Periodontal treatment influences risk markers for atherosclerosis in patients with severe periodontitis
Atherosclerosis, 10/09/2009
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Buhlin K et al. – This study indicates that standard treatment for periodontal disease induces systemic changes in several biochemical markers that reflect the risk for atherosclerosis.
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Liver X Receptors as potential therapeutic targets in atherosclerosis
Clinical and Investigative Medicine, 10/06/2009
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Zhu Y et al. – LXR –selective agonists and LXR modulators, which act as agonists in macrophages and induce cholesterol efflux while as antagonists of lipogenesis in the liver, are two critical and attractive approaches to treat atherosclerosis and ... diseases.
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Microarray analysis of senescent vascular smooth muscle cells: A link to atherosclerosis and vascular calcification
Experimental Gerontology, 11/12/2009
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Burton DA et al. – These data provide the first evidence for a role of vascular smooth muscle cells (VSMCs) senescence in the development of vascular calcification and provides ... progression of atherosclerosis.
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Effects of High-Dose Modified-Release Nicotinic Acid on Atherosclerosis and Vascular Function: A Randomized, Placebo-Controlled, Magnetic Resonance Imaging Study
JACC - Journal of the American College of Cardiology, 10/29/2009
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Lee JMS et al. – In statin–treated patients with low HDL–C, high–dose modified–release NA, compared with placebo, significantly reduces carotid atherosclerosis ... within 12 months.
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Blood Glutathione and Subclinical Atherosclerosis in African Men: The SABPA Study
American Journal of Hypertension, 10/28/2009
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Schutte R et al. – In hypertensive African men, CIMT is negatively associated with GSH, suggesting a possible contributory role of attenuated GSH levels in the development of subclinical atherosclerosis.
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Effects of Bariatric Surgery on Inflammatory, Functional and Structural Markers of Coronary Atherosclerosis
The American Journal of Cardiology, 10/21/2009
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Habib P et al. – GBS results in significant improvements in inflammatory, structural, and functional markers of coronary atherosclerosis.
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18F-4V for PET–CT Imaging of VCAM-1 Expression in Atherosclerosis
JACC - Journal of the American College of Cardiology: Cardiovascular Imaging, 10/19/2009
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Nahrendorf M et al. – 18F–4V allows noninvasive PET–CT imaging of VCAM–1 in inflammatory atherosclerosis, has the dynamic range to quantify treatment effects, and correlates with inflammatory gene expression.
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High-Density Lipoprotein–Based Contrast Agents for Multimodal Imaging of Atherosclerosis
Arteriosclerosis, Thrombosis, and Vascular Biology, 10/16/2009
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Skajaa T et al. – By rerouting of HDL away from plaque macrophages, imaging of biological processes in diseases besides atherosclerosis may also be achieved.
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