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See Latest ArticlesA novel composite endpoint to evaluate the gastrointestinal (GI) effects of nonsteroidal antiinflammatory drugs through the entire GI tract
Journal of Rheumatology, 11/18/09
Chan FKL et al. – By providing clinicians with a new, descriptive language for adverse events through the entire GI tract, the CSULGIE endpoint has the potential to become a standard tool for evaluating the GI effects of a range of therapies.
Methods- Reviewed data from largescale, multicenter, randomized, clinical trials on lower GI toxicity associated with NSAID use
- Rationale for using CSULGIE as primary endpoint in 2 ongoing trials — the Celecoxib vs Omeprazole and Diclofenac for At-risk OA and RA Patients (CONDOR) trial and Gastrointestinal Randomized Events and Safety Open-Label NSAID Study (GI-REASONS) discussed
- Previous randomized trials focused primarily on damage to upper GI tract and often neglected lower GI tract
- CSULGIE endpoint extends traditional “perforation, obstruction, and bleeding” assessment of upper GI complications by including events in lower GI tract (small/large bowel) such as perforation, bleeding, and clinically significant anemia
Today in Clinical Pharmacology...keeping you current
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Olanzapine versus other atypical antipsychotics for schizophrenia
Cochrane Reviews, 03/19/10
Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis
Cochrane Reviews, 03/19/10
Fibrinolytic agents for peripheral arterial occlusion
Cochrane Reviews, 03/19/10
Today in Gastroenterology...keeping you current
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Zinc Influences the Innate Immune Responses in Children with Enterotoxigenic Escherichia coli-Induced Diarrhea
The Journal of Nutrition, 03/19/10
Un-promoted issues in inflammatory bowel disease: opportunities to optimize care
Internal Medicine Journal, 03/19/10
Unsuspected Malabsorption Syndrome Causing Acute Oxalate Nephropathy
Clinical Geriatrics, 03/19/10
Today in Clinical Pharmacology...keeping you current
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Olanzapine versus other atypical antipsychotics for schizophrenia
Cochrane Reviews, 03/19/10
Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis
Cochrane Reviews, 03/19/10
Fibrinolytic agents for peripheral arterial occlusion
Cochrane Reviews, 03/19/10
Today in Gastroenterology...keeping you current
Receive free subspecialty "5-minute updates" via email
Un-promoted issues in inflammatory bowel disease: opportunities to optimize care
Internal Medicine Journal, 03/19/10
Medical versus surgical management for gastro-oesophageal reflux disease (GORD) in adults
Cochrane Reviews, 03/19/10
Practical guidelines for treating inflammatory bowel disease safely with anti-tumour necrosis factor therapy in Australia
Internal Medicine Journal, 03/19/10
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A review of the effect of anticonvulsant medications on bone mineral density and fracture risk
The American Journal of Geriatric Pharmacotherapy, 03/19/10
Severe exfoliative dermatitis caused by strontium ranelate: two cases of a new drug reaction
Age and Aging, 03/19/10
A walking model to assess the onset of analgesia in osteoarthritis knee pain
Osteoarthritis and Cartilage , 03/19/10
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