Gastro Medical News about Liver Transplantation

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Lack of killer immunoglobulin-like receptor 2DS2 (KIR2DS2) and KIR2DL2 is associated with poor responses to therapy of recurrent hepatitis C virus in liver transplant recipients
Liver Transplantation, 11/03/09

Askar M et al. – The findings support the role of natural killer and natural killer T cells in HCV clearance after LT and might be generalizable to treatment of HCV infection outside the setting of LT.

Exclusive Author Commentary
Medhat Askar, 11/08/09

The immunogenetic factors influencing the antiviral potential of NK cells particularly activating killer cell immunoglobulin-like receptor (KIR) genes have been implicated in the outcomes of human immunodeficiency virus, herpes simplex virus, cytomegalovirus, and HCV infections. This study investigates the same paradigm in relation to the responsiveness to peginterferon/ribavirin combination therapy (Peg/RBV) in recurrent HCV infection post-transplant (LT). Results of this study provide preliminary data suggesting that the presence of KIR2DS2 and/or KIR2DL2 might be critical for an immune-enhancing effect on the responses to Peg/RBV in liver transplant recipients with recurrent HCV. Although we have studied these responses in the post-LT settings, the observed association may be generalizable to treatment of HCV infection outside the setting of LT, and can potentially provide further insight into innate anti-HCV immune mechanisms.

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