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A Prospective Cohort Study Shows Unique Epigenetic, Genetic, and Prognostic Features of Synchronous Colorectal Cancers
Gastroenterology, 10/28/09
Nosho K et al. – Synchronous colorectal cancers had more frequent mutations in BRAF, were more frequently CIMP– and MSI–high, and had a worse prognosis than solitary colorectal cancers. Similar epigenomic and epigenetic events were frequently observed within a synchronous cancer pair, suggesting the presence of a field defect.
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