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See Latest ArticlesMeta- and Pooled Analyses of the Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Colorectal Cancer: A HuGE-GSEC Review
American Journal of Epidemiology, 10/22/09
Taioli E et al. – The MTHFR 677TT polymorphism seems to be associated with a reduced risk of CRC, but this may not hold true for all populations.
Methods- The authors performed both a meta–analysis (29 studies; 11,936 cases, 18,714 controls) and a pooled analysis (14 studies; 5,068 cases, 7,876 controls) of the C677T MTHFR polymorphism and CRC, with stratification by racial/ethnic population and behavioral risk factors.
- There were few studies on different racial/ethnic populations.
- The overall meta–analysis odds ratio for CRC for persons with the TT genotype was 0.83.
- An inverse association was observed in whites and Asians but not in Latinos or blacks.
- Similar results were observed for Asians, Latinos, and blacks in the pooled analysis.
- Similar results were observed for Asians, Latinos, and blacks in the pooled analysis.
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