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Decrease in nerve fibre density in human sigmoid colon circular muscle occurs with growth but not aging
Neurogastroenterology and Motility, 10/19/09
Southwell BR et al. – In human sigmoid colon circular muscle, there are reductions in nNOS–, VIP– and SP–IR nerve fibre density with growth from newborn to late adolescence but little further change with aging. The reduction in nerve density is due to an increase in circular muscle thickness rather than a loss of nerve fibres.
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