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Cyclooxygenase-2 Inhibitors Down-regulate Osteopontin and Nr4a2-New Therapeutic Targets for Colorectal Cancers
Gastroenterology, 10/07/09
Zagani R et al. – Down–regulation of osteopontin, probably through blockade of NR4A2 and Wnt signaling, is an important component of the antitumor activity of cyclooxygenase–2 inhibitors. These factors might be developed as therapeutic targets for intestinal cancers.
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