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Du YC et al. – Sox17 plays a tumor suppressor role through suppression of Wnt signaling. However, Sox17 is induced by Wnt activation in the early stage of gastrointestinal tumorigenesis, and Sox17 is down–regulated by methylation during malignant progression. It is therefore conceivable that Sox17 protects benign tumors from malignant progression at an early stage of tumorigenesis, and down–regulation of Sox17 contributes to malignant progression through promotion of Wnt activity.

Today in Basic Science/Genetics...keeping you current

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