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Involvement of interleukin-15 and interleukin-21, two gamma-chain-related cytokines, in celiac disease
World Journal of Gastroenterology, 10/07/09
De ND et al. – Celiac disease (CD), an enteropathy caused by dietary gluten in genetically susceptible individuals, is histologically characterized by villous atrophy, crypt cell hyperplasia, and increased number of intra–epithelial lymphocytes. The nature of CD pathogenesis remains unclear, but recent evidence indicates that both innate and adaptive immune responses are necessary for the phenotypic expression and pathologic changes characteristic of CD.
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