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See Latest ArticlesPriming of CD4+ T cells by liver sinusoidal endothelial cells induces CD25low forkhead box protein 3- regulatory T cells suppressing autoimmune
Hepatology, 09/30/09
Klugewitz K et al. – The authors findings strengthen the previously discussed assumption that CD4+ T cell priming by nonprofessional antigen–presenting cells induces anti–inflammatory rather than proinflammatory phenotypes. Because recruitment of CD4+ T cells is increased upon hepatic inflammation, TLSEC might contribute to shifting antigen–dependent immune responses to tolerance toward exogenous antigens or toward endogenous self–antigens, especially under inflammatory conditions.
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