Gastro Medical News about Proton Pump Inhibitors Drug Toxicity

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Long-term Safety Concerns with Proton Pump Inhibitors
American Journal of Medicine, 09/29/09

Ali T et al. – To provide a comprehensive review regarding the concerns of long–term PPI use, a literature search was performed to identify pertinent original and review articles. Despite study shortcomings, the collective body of information overwhelmingly suggests an increased risk of infectious complications and nutritional deficiencies. Data regarding any increased risk in gastric or colon malignancy are less convincing. PPIs have revolutionized the management and complications of acid–related disorders with a high margin of safety; however, with the data available, efforts to reduce the dosing of or discontinue the use of PPIs must be reassessed frequently.

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