Gastro Medical News about Inflammatory Bowel Diseases

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Adenosine: An immune modulator of inflammatory bowel diseases
World Journal of Gastroenterology, 10/06/09

Ye JH et al. – Inflammatory bowel disease (IBD) is a common and lifelong disabling gastrointestinal disease. Emerging treatments are being developed to target inflammatory cytokines which initiate and perpetuate the immune response. Adenosine is transported via concentrative nucleoside transporter and equilibrative nucleoside transporter transporters that are localized in apical and basolateral membranes of intestinal epithelial cells, respectively. Increased extracellular adenosine levels activate the A2a receptor, which would reduce cytokines responsible for chronic inflammation.

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