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Okayasu I et al. – Deposits of Masson's trichrome+ and type III and I collagen in the muscularis mucosae and lamina propria appeared to increase in relation to the numbers of alpha–SMA+ interstitial cells. Mucosal remodeling with alterations of NCAM+ or alpha–SMA+ subepithelial and interstitial cells may play a critical role in UC–associated tumorigenesis.

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