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Changes of peripheral alpha-melanocyte–stimulating hormone in childhood obesity
Metabolism-Clinical and Experimental, 10/13/09

Roth CL et al. – The alpha–MSH changes correlated to weight status changes but not to changes of cortisol, insulin, or homeostasis model assessment of insulin resistance index. Persistently low alpha–MSH levels in CP patients are suspected to be due to pituitary or hypothalamic damage. High peripheral levels in MC4Rmut carriers indicate up–regulation of alpha–MSH. Changes of weight status are associated with changes of peripheral alpha–MSH.

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