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Cutoff value determines the performance of a semi-quantitative immunochemical faecal occult blood test in a colorectal cancer screening programme
British Journal of Cancer, 09/17/09

van Rossum LGM et al. – Cutoffs below the standard 100 ng ml^–1 resulted in not only higher detection rates of advanced lesions but also more colonoscopies. With sufficient capacity, 75 ng ml^–1 might be advised; if not, up to 200 ng ml^–1 CRC miss rates are acceptable compared with the decrease in performed colonoscopies.

Exclusive Author Commentary
LGM van Rossum, 09/18/09

A choice for a cutoff in the balance between the benefit colorectal cancer detection and the harm of an – in hindsight - unnecessary colonoscopy can only be arbitrary. We hope this manuscript will help major stakeholders to make balanced decisions.

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