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Aljiffry M et al. – Several advances in diagnosis, treatment and palliation of cholangiocarcinoma (CC) have occurred in the last decades. CC is a relatively rare tumor and the main risk factors are: chronic inflammation, genetic predisposition and congenital abnormalities of the biliary tree. While the incidence of intra–hepatic CC is increasing, the incidence of extra–hepatic CC is trending down. The only curative treatment for CC is surgical resection with negative margins. Liver transplantation has been proposed only for selected patients with hilar CC that cannot be resected who have no metastatic disease after a period of neoadjuvant chemo–radiation therapy.


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