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Di Marzo V et al. – Endocannabinoids control metabolism via cannabinoid CB1 receptors. Their plasma levels are elevated in overweight type 2 diabetes (T2D) and in obese patients, and decrease post–prandially in normoweight individuals. Insulin reduces endocannabinoid levels in a way inversely related to anthropometric and metabolic predictors of insulin resistance and dyslipidemia.

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