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Prevention of hepatocellular carcinoma in hepatitis B virus infection
Journal of Gastroenterology and Hepatology, 09/04/09
Lim SG et al. – It is now possible to prevent HBV–related HCC. The most effective method is hepatitis B vaccination, which prevents chronic HBV infection and chronic liver disease resulting therefrom. Interferon therapy appears to confer benefit but the evidence is weaker. First–generation oral antiviral (lamivudine) reduces HCC risk, particularly in cirrhotics. Long–term outcome data with newer, more potent HBV antivirals that have a higher genetic barrier to drug resistance are eagerly awaited.
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