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See Latest ArticlesRole of the C5a receptor (C5aR) in acute and chronic dextran sulfate-induced models of inflammatory bowel disease
Inflammatory Bowel Disease, 09/02/09
Klos A et al. – C5aR exerts detrimental functions in acute colitis, strongly supporting the idea that a C5aR–antagonist might be useful for IBD treatment. However, since the absence of C5aR was no longer protective and in some regards disadvantageous in chronic IBD, future studies should address the efficacy and the possible side effects of a sustained antagonist treatment.
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