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Zhao J et al. – COX–2 might play an important role in the progress of ESCC, overexpression of COX–2 correlates with not only the depth of invasion and TNM stage but also the reduced OS. COX–2 might be a potential therapy target for ESCC and work as a prognostic factor for ESCC patients, yet the clinicopathological and prognostic role of COX–2 in ESCC still needs further confirmation by well–designed prospective studies.

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