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Activation of protease-activated receptor-4 inhibits the intrinsic excitability of colonic dorsal root ganglia neurons
Neurogastroenterology and Motility, 08/27/09
Vanner S et al. – The findings demonstrated that activation of PAR4 on colonic DRG neurons suppresses their excitability, suggesting these receptors could provide important targets for modifying pain in colonic GI disorders such as IBS and IBD.
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