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See Latest ArticlesReview article: visceral hypersensitivity in irritable bowel syndrome: molecular mechanisms and therapeutic agents
Alimentary Pharmacology and Therapeutics, 08/04/09
Ghosh S et al. – There is substantial interest in the development of new drugs for treatment of FBDs in the background of advances in understanding the molecular and physiological mechanisms of visceral hypersensitivity. The potential drug targets include TPRV1, ASICs, voltage–gated sodium channels, ATP, PAR–2, cannabinoid, prostaglandin, tachykinin and 5HT3 receptors. It is anticipated that with advancing molecular understanding of the basis of visceral hypersensitivity, the next decade will see accelerated development of new molecules for treatment of functional bowel diseases.
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