Your Article Summary
See Latest ArticlesPredictors of long-term survival after resection of esophageal carcinoma with nonregional nodal metastases
Annals of Thoracic Surgery, 07/01/09
Lee FC et al. - In a study to analyze factors predicting long-term survival in patients with esophageal carcinoma and celiac, cervical, or other nonregional nodal metastases, it apears that surgical resection for pts with esophageal cancer associated with nonregional nodal metastases results in 25% survival at 5 yrs. Squamous histology, earlier T status, and perioperative chemotherapy are independent positive predictors of long-term survival.
Methods- A retrospective review was conducted of a prospective database over a 20-yr period to identify pts with resected esophageal carcinoma with nonregional lymph node metastases.
- Medical records were reviewed and risk factors were analyzed.
- 67 pts underwent esophagectomy for M1a or M1b disease.
- Esophagectomy was transthoracic in 62 pts and transhiatal in 5.
- Median number of lymph nodes harvested was 36.
- Sites of nodal metastases were the following: recurrent nodal chain in 42 pts, celiac in 20, both recurrent and celiac in 4, and paratracheal in 1.
- Median length of follow-up was 66 mos; 5-yr overall survival (OS) for the cohort was 25%; 5-yr OS was significantly higher with earlier T-status.
- 13 pts who had nonregional nodal metastases without involvement of regional nodes (pN0) had a significant improvement in 5-yr survival (67% vs 15%).
- Pts with squamous cell carcinomas had higher 5-yr survival vs those with adenocarcinomas (42% vs 14%).
- Pts treated with induction chemotherapy had prolonged 5-yr survival (41%) vs those treated with adjuvant chemotherapy (11%) or no therapy (20%).
- Multivariate analysis demonstrated that chemotherapy treatment, squamous cell type, and early T stage (pT1/T2) are significant positive predictors of survival.
Related Articles
The incidence and risk of developing a second primary esophageal cancer in patients with oral and pharyngeal carcinoma: a population-based study in Taiwan over a 25 year period
BMC Cancer, 11/02/09
Relevance Score: 67%
Detection of metachronous esophageal squamous carcinoma in patients with head and neck cancer with use of transnasal esophagoscopy
Head & Neck, 11/06/09
Relevance Score: 66%
A Critical Appraisal of Circumferential Resection Margins in Esophageal Carcinoma
Annals of Surgical Oncology, 11/23/09
Relevance Score: 65%
Increasing trend of the incidence of esophageal squamous cell carcinoma, but not adenocarcinoma, in Taiwan
Cancer Causes and Control, 11/04/09
Relevance Score: 65%
Long-term survivors of esophageal cancer: Disease-specific quality of life, general health and complications
Journal of Surgical Oncology, 11/02/09
Relevance Score: 65%
Today in Esophagus...keeping you current
Receive free subspecialty "5-minute updates" via email
Nausea Caused by a Jejunal Lipoma
Clinical Gastroenterology and Hepatology , 12/14/09
A laparoscopic vagus-preserving Merendino procedure for early esophageal adenocarcinoma
Surgical Endoscopy, 12/14/09
Pre-operative dental brushing can reduce the risk of postoperative pneumonia in esophageal cancer patients
Surgery, 12/14/09
Today in GI Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
Are patients of low socioeconomic status receiving suboptimal management for pancreatic adenocarcinoma
Cancer, 12/14/09
Nausea Caused by a Jejunal Lipoma
Clinical Gastroenterology and Hepatology , 12/14/09
Glutathione-S-transferase (GSTM1, GSTT1) and the risk of gastrointestinal cancer in a Korean population
World Journal of Gastroenterology, 12/14/09