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The impact of obesity on outcomes following pancreatectomy for malignancy
Annals of Surgical Oncology, 06/29/09

Benns M et al. - In a study to determine the impact of obesity on operative outcomes, recurrence, and overall survival, it appears that obese pts had a higher rate and greater severity of postoperative complications, with increased operative blood loss. Obese pts did not demonstrate any significant difference in specific oncologic factors or survival. These data suggest an equivalent biologic effect of obesity on pancreatic cancer survival.

Methods

A review of a 1345 pt prospective hepatopancreaticobiliary database was performed to identify pts undergoing pancreatic resection for adenocarcinoma.
Obesity was defined as a body mass index (BMI) >30 kg/m2.
Data were analyzed using Wilcoxon, t test, and chi-square methods.
Survival was analyzed using log-rank analysis.
Postoperative complications were assessed using a 5-point scale.

Results

Of 306 pts undergoing pancreatic resection for pancreatic adenocarcinoma examined, 68 were defined as obese.
There was no significant difference seen in length of stay, operative time, tumor size, or node status.
Obese pts had a higher operative blood loss and were more likely to suffer postoperative complications (67.6% vs 50.4%).
There was no significant difference seen in disease-free survival or overall survival (22.1 mos for obese vs 25.6 mos for nonobese; 19.8 mos for obese vs 23.5 mos for nonobese).

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