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Boland CR et al. - This paper reviews the types of genetic alterations that can be found in CRCs and hepatocellular carcinoma (HCC), and focuses upon the epigenetic alterations that result in promoter methylation and the CpG island methylator phenotype (CIMP). The challenge facing CRC research and clinical care at this time is to deal with the heterogeneity and complexity of these genetic and epigenetic alterations, and to use this information to direct rational prevention and treatment strategies.

Today in Basic Science/Genetics...keeping you current

Polymorphisms of the apoptosis-associated gene DP1L1 (deleted in polyposis 1-like 1) in colon cancer and inflammatory bowel disease
Journal of Cancer Research & Clinical Oncology, 12/04/09

Polymorphism in the oxytocin promoter region in patients with lactase non-persistence is not related to symptoms
BMC Gastroenterology, 12/04/09

Variants in the UGT1A1 Gene and the Risk of Pediatric Nonalcoholic Fatty Liver Disease
Pediatrics, 12/02/09